Exploiting Hydration Hysteresis for High Activity of Cross-Linked Subtilisin Crystals in Acetonitrile Johann Partridge, Gillian A. Hutcheon, Barry D. Moore, and Peter J. Halling — pp 12873-12877 Multidimensional Marcus Theory: An Analysis of Concerted Reactions J. Peter Guthrie — pp 12878-12885 Intrinsic Barriers for Proton Transfer Reactions Involving Electronegative Atoms,...
Redox-Triggered Secondary Structure Changes in the Aggregated States of a Designed Methionine-Rich Peptide Heather L. Schenck, Gregory P. Dado, and Samuel H. Gellman — pp 12487-12494 Solvent-Accelerated Decarboxylation of N-Carboxy-2-imidazolidinone. Implications for Stability of Intermediates in Biotin-Dependent Carboxylations Jubrail Rahil, Shaochun You, and Ronald Kluger —...
Electrostatic Acceleration of Enolization in Cationic Ketones John B. Tobin and Perry A. Frey — pp 12253-12260 Inductive Effects on the Energetics of Prolyl Peptide Bond Isomerization: Implications for Collagen Folding and Stability Eric S. Eberhardt, Nicholas Panasik, and Ronald T. Raines — pp 12261-12266 Syntheses, Structures, and Transannular π−π Interactions of Multibridged...
Design, Synthesis, and Analysis of Disulfide Cross-Linked DNA Duplexes Scott E. Osborne, Jens Völker, Shawn Y. Stevens, Kenneth J. Breslauer, and Gary D. Glick — pp 11993-12003 Toward a Mechanism-Based Fluorescent Assay for Site-Specific Recombinases and Topoisomerases: Assay Design and Syntheses of Fluorescent Substrates Gagan Panigrahi, Bao-ping Zhao, Jiri J. Krepinsky, and...
On Protein Denaturation in Aqueous−Organic Mixtures but Not in Pure Organic Solvents Kai Griebenow and Alexander M. Klibanov — pp 11695-11700 Alteration of DNA Primary Structure by DNA Topoisomerase I. Isolation of the Covalent Topoisomerase I−DNA Binary Complex in Enzymatically Competent Form Kristine A. Henningfeld, Tuncer Arslan, and Sidney M. Hecht — pp 11701-11714...
Nucleic Acid Related Compounds. 91. Biomimetic Reactions Are in Harmony with Loss of 2‘-Substituents as Free Radicals (Not Anions) during Mechanism-Based Inactivation of Ribonucleotide Reductases. Differential Interactions of Azide, Halogen, and Alkylthio Groups with Tributylstannane and Triphenylsilane1 Morris J. Robins, Stanislaw F. Wnuk, Amelia E. Hernández-Thirring, and...
Electron Transfer Photochemistry of Geraniol and (E,E)-Farnesol. A Novel “Tandem”, 1,5-Cyclization, Intramolecular Capture Hengxin Weng, Christopher Scarlata, and Heinz D. Roth — pp 10947-10953 Electron Transfer Photochemistry of Chrysanthemol: An Intramolecular SN2‘ Reaction of a Vinylcyclopropane Radical Cation Torsten Herbertz and Heinz D. Roth — pp 10954-10962 Hydrolysis of...
A DNA−Lipid Complex in Organic Media and Formation of an Aligned Cast Film1 Kentaro Tanaka and Yoshio Okahata — pp 10679-10683 Specific Recognition of Substrate Analogs by the DNA Mismatch Repair Enzyme MutY Silvia L. Porello, Scott D. Williams, Heiko Kuhn, Mark L. Michaels, and Sheila S. David — pp 10684-10692 Molecular Anchoring of Duplex and Triplex DNA by Disubstituted...
Synthesis and Characterization of an RNA Dinucleotide Containing a 3‘-S-Phosphorothiolate Linkage Lara B. Weinstein, David J. Earnshaw, Richard Cosstick, and Thomas R. Cech — pp 10341-10350 Acetyl-Terminated and Template-Assembled Collagen-Based Polypeptides Composed of Gly-Pro-Hyp Sequences. 2. Synthesis and Conformational Analysis by Circular Dichroism, Ultraviolet...
Cooperative Oligomerization Enhances Sequence-Selective DNA Binding by a Short Peptide Takashi Morii, Junji Yamane, Yasunori Aizawa, Keisuke Makino, and Yukio Sugiura — pp 10011-10017 Cyclic Peptides from Linear Unprotected Peptide Precursors through Thiazolidine Formation Paolo Botti, T. David Pallin, and James P. Tam — pp 10018-10024 A Novel Mechanism for the Formation of...
PH Control of the Catalytic Activity of Cross-Linked Enzyme Crystals in Organic Solvents Kui Xu and Alexander M. Klibanov — pp 9815-9819 Facilitated Catecholamine Transport through Bulk and Polymer-Supported Liquid Membranes Marie-France Paugam, Jeffrey T. Bien, Bradley D. Smith, Lysander A. J. Chrisstoffels, Feike de Jong, and David N. Reinhoudt — pp 9820-9825 A Stereochemical...
Unprecedented Mild Acid-Catalyzed Desilylation of the 2‘-O-tert-Butyldimethylsilyl Group from Chemically Synthesized Oligoribonucleotide Intermediates via Neighboring Group Participation of the Internucleotidic Phosphate Residue Shun-ichi Kawahara, Takeshi Wada, and Mitsuo Sekine — pp 9461-9468 Chlorin-Oligonucleotide Conjugates: Synthesis, Properties, and Red Light-Induced...
2,7-Diaminomitosene, a Monofunctional Mitomycin C Derivative, Alkylates DNA in the Major Groove. Structure and Base-Sequence Specificity of the DNA Adduct and Mechanism of the Alkylation Gopinatha Suresh Kumar, Steven M. Musser, Jeffrey Cummings, and Maria Tomasz — pp 9209-9217 Pseudo-Prolines as a Solubilizing, Structure-Disrupting Protection Technique in Peptide Synthesis...
Synthetic Melittin, Its Enantio, Retro, and Retroenantio Isomers, and Selected Chimeric Analogs: Their Antibacterial, Hemolytic, and Lipid Bilayer Action Padmaja Juvvadi, Satyanarayana Vunnam, and R. B. Merrifield — pp 8989-8997 Peptide Mimetic of the Third Cytoplasmic Loop of the PTH/PTHrP Receptor Dale F. Mierke, Miriam Royo, Maria Pellegrini, Hongmao Sun, and Michael Chorev...
Equilibrium Acidities and Homolytic Bond Dissociation Energies of N−H and/or O−H Bonds in N-Phenylhydroxylamine and Its Derivatives Frederick G. Bordwell and Wei-Zhong Liu — pp 8777-8781 Systematically Cross-Linked Human Hemoglobin: Functional Effects of 10 Å Spans between Beta Subunits at Lysine-82 Ronald Kluger, Lixin Shen, Hong Xiao, and Richard T. Jones — pp 8782-8786 A...
A Novel Bicyclic Enzyme Inhibitor as a Consensus Peptidomimetic for the Receptor-Bound Conformations of 12 Peptidic Inhibitors of HIV-1 Protease Robert C. Reid, Darren R. March, Michael J. Dooley, Doug A. Bergman, Giovanni Abbenante, and David P. Fairlie — pp 8511-8517 Comparative Total Syntheses of Turkey Ovomucoid Third Domain by Both Stepwise Solid Phase Peptide Synthesis...
A Practical Method for the Synthesis of Sialyl α-Glycosides Valeri Martichonok and George M. Whitesides — pp 8187-8191 Electron Paramagnetic Resonance Investigations of a Kinetically Competent Intermediate Formed in Ribonucleotide Reduction: Evidence for a Thiyl Radical-Cob(II)alamin Interaction G. J. Gerfen, S. Licht, J.-P. Willems, B. M. Hoffman, and J. Stubbe — pp 8192-8197...
Photoreactions of γ,δ-Unsaturated Chromium Carbene Complexes William H. Moser and Louis S. Hegedus — pp 7873-7880 Cyclic RGD Peptides Containing β-Turn Mimetics Roland Haubner, Wolfgang Schmitt, Günter Hölzemann, Simon L. Goodman, Alfred Jonczyk, and Horst Kessler — pp 7881-7891 Association of Short-Strand DNA Oligomers with Guanidinium-Linked Nucleosides. A Kinetic and...
Enzymatic/Chemical Synthesis and Biological Evaluation of Seven-Membered Iminocyclitols Francisco Morís-Varas, Xin-Hua Qian, and Chi-Huey Wong — pp 7647-7652 Synergistic Inhibition of Human α-1,3-Fucosyltransferase V Lei Qiao, Brion W. Murray, Makoto Shimazaki, Jody Schultz, and Chi-Huey Wong — pp 7653-7662 Incorporation of Two Oxygens from 18O2 in the Epoxyquinone from the...
Crystal Structure of 6α-(Hydroxymethyl)penicillanate Complexed to the TEM-1 β-Lactamase from Escherichia coli: Evidence on the Mechanism of Action of a Novel Inhibitor Designed by a Computer-Aided Process Laurent Maveyraud, Irina Massova, Catherine Birck, Kazuyuki Miyashita, Jean-Pierre Samama, and Shahriar Mobashery — pp 7435-7440 Evidence for Structural Elasticity of Class A...
Three-Center, Two-Electron Systems. Origin of the Tilting of Their Substituents Koop Lammertsma and Tomohiko Ohwada — pp 7247-7254 Redox Reaction of Benzyl Radicals with Aromatic Radical Ions Photogenerated. The Marcus Inverted Region and the Selective Formation of Carbocations or Carbanions Katsuya Ishiguro, Tomoharu Nakano, Hiroki Shibata, and Yasuhiko Sawaki — pp 7255-7264...
Structural and Dynamic Characterization of Pro Cis/Trans Isomerization in a Small Cyclic Peptide C. Francart, J.-M. Wieruszeski, A. Tartar, and G. Lippens — pp 7019-7027 Preferential Adsorption of a “Kinked” DNA to a Neutral Curved Surface: Comparisons to and Implications for Nonspecific DNA−Protein Interactions Rahina Mahtab, Jessica P. Rogers, Chainey P. Singleton, and...
A Noncleavable Retro-Binding Peptide That Spans the Substrate Binding Cleft of Serine Proteases. Atomic Structure of Nazumamide A: Human Thrombin Vicki L. Nienaber and Eugene C. Amparo — pp 6807-6810 Tautomerism and Protonation of Guanine and Cytosine. Implications in the Formation of Hydrogen-Bonded Complexes Carles Colominas, Francisco J. Luque, and Modesto Orozco — pp...
Solution Structures of i to i + 3 Cyclized Model Peptides: Building Blocks Mimicking Specific Conformations Hanumantha Rao Marepalli, Octavian Antohi, Jeffrey M. Becker, and Fred Naider — pp 6531-6539 Isotope-Edited Infrared Linear Dichroism: Determination of Amide Orientational Relationships Todd S. Anderson, John Hellgeth, and Peter T. Lansbury — pp 6540-6546 Regiochemical...
The Macrobicyclic Cryptate Effect in the Gas Phase Qizhu Chen, Kevin Cannell, Jeremy Nicoll, and David V. Dearden — pp 6335-6344 Chiral Discrimination in DNA−Peptide Interactions Involving Chiral DNA Mesophases: A Geometric Analysis Ziv Reich, Oded Schramm, Vlad Brumfeld, and Abraham Minsky — pp 6345-6349 Using Incoming Group 11C/14C Kinetic Isotope Effects To Model the...
JACS on the Internet pp 6099-6100 Sialyl Lewis x Liposomes as a Multivalent Ligand and Inhibitor of E-Selectin Mediated Cellular Adhesion Shawn A DeFrees, Laurie Phillips, Luke Guo, and Samuel Zalipsky — pp 6101-6104 Rates of Uncatalyzed Peptide Bond Hydrolysis in Neutral Solution and the Transition State Affinities of Proteases Anna Radzicka and Richard Wolfenden — pp...
Artificial Sequence-Specific DNA Binding Peptides: Branched-Chain Basic Regions Matthew Pellegrini and Richard H. Ebright — pp 5831-5835 A 2,3‘-Substituted Biphenyl-Based Amino Acid Facilitates the Formation of a Monomeric β-Hairpin-like Structure in Aqueous Solution at Elevated Temperature Carey L. Nesloney and Jeffery W. Kelly — pp 5836-5845 Irreversible Inhibition of the...
Energetic Effects of Multiple Hydrogen Bonds. Implications for Enzymatic Catalysis Shu-ou Shan and Daniel Herschlag — pp 5515-5518 Activated Ketones as Inhibitors of Intracellular Ca2+-Dependent and Ca2+-Independent Phospholipase A2 Kilian Conde-Frieboes, Laure J. Reynolds, Yi-Ching Lio, Michael R. Hale, Harry H. Wasserman, and Edward A. Dennis — pp 5519-5525 Electrostatic and...
Inactivation of Etamycin by a Novel Elimination Mechanism in Streptomyces lividans Kevin P. Bateman, Keqian Yang, Pierre Thibault, Robert L. White, and Leo C. Vining — pp 5335-5338 Double-Strand Cleavage of DNA by a Monofunctional Transition Metal Cleavage Agent Filomena V. Pamatong, Charles A. Detmer, and Jeffrey R. Bocarsly — pp 5339-5345 Liquid Crystal Control of Bimolecular...
A Two-State Model of Hydrophobic Hydration That Produces Compensating Enthalpy and Entropy Changes B. Lee and Giuseppe Graziano — pp 5163-5168 Generation and Detection of a Relatively Persistent Carboxylic Acid Enol2,2-Bis(2‘,4‘,6‘-triisopropylphenyl)ethene-1,1-diol Joseph Frey and Zvi Rappoport — pp 5169-5181 Reactions of the Relatively Persistent Carboxylic Acid...
Photoinduced Electron Transfer Chemistry of 9-Methylanthracene. Substrate as Both Electron Donor and Acceptor in the Presence of the 1-Ethyl-3-methylimidazolium Ion Carlos Lee, Timothy Winston, Additya Unni, Richard M. Pagni, and Gleb Mamantov — pp 4919-4924 Crystal and Electronic Structure of Stable Nitrenium Ions. A Comparison with Structurally Related Carbenes Gernot Boche,...
Base Specific and Regioselective Chemical Cross-Linking of Daunorubicin to DNA Fenfei Leng, Rajesh Savkur, Izabela Fokt, Teresa Przewloka, Waldemar Priebe, and Jonathan B. Chaires — pp 4731-4738 A Cationic Cyclophane That Forms a Base-Pair Open Complex with RNA Duplexes M. Fernandez-Saiz, H.-J. Schneider, J. Sartorius, and W. David Wilson — pp 4739-4745 Mechanistic Studies of...
Identification of Conformational Substates in Oxymyoglobin through the pH-Dependence of the Low-Temperature Photoproduct Yield Lisa M. Miller, Mehul Patel, and Mark R. Chance — pp 4511-4517 Nonionic Analogs of RNA with Dimethylene Sulfone Bridges Clemens Richert, Andrew L. Roughton, and Steven A. Benner — pp 4518-4531 Temperature Dependence and Sequence Specificity of DNA...
Cyclic Guanidino-Sugars with Low pKa as Transition-State Analog Inhibitors of Glycosidases: Neutral Instead of Charged Species Are the Active Forms Jin-Hyun Jeong, Brion W. Murray, Shuichi Takayama, and Chi-Huey Wong — pp 4227-4234 Can the Monomer of the Leucine Zipper Proteins Recognize the Dimer Binding Site without Dimerization? Changmoon Park, Judy L. Campbell, and William...
NMR Studies of a 13C,15N-Labeled GM4-Lactam Glycolipid at an Oriented Model-Membrane Interface Brian A. Salvatore, Ranajeet Ghose, and James H. Prestegard — pp 4001-4008 2-Pyridylnitrene−1,3-Diazacyclohepta-1,2,4,6-tetraene Rearrangements in the Trifluoromethyl-2-pyridyl Azide Series1a Richard A. Evans, Ming Wah Wong, and Curt Wentrup — pp 4009-4017 Engineering the Solid State...
Polyacrylamides Bearing Pendant α-Sialoside Groups Strongly Inhibit Agglutination of Erythrocytes by Influenza Virus: The Strong Inhibition Reflects Enhanced Binding through Cooperative Polyvalent Interactions George B. Sigal, Mathai Mammen, Georg Dahmann, and George M. Whitesides — pp 3789-3800 Lipase-Catalyzed Second-Order Asymmetric Transformations as Resolution and...
Antioxidant Activities of Vitamin E Analogues in Water and a Kamlet−Taft β-Value for Water1 Luca Valgimigli, K. U. Ingold, and J. Lusztyk — pp 3545-3549 A Nitroxyl Synthase Catalytic Antibody Nicolaus Bahr, Rolf Güller, Jean-Louis Reymond, and Richard A. Lerner — pp 3550-3555 Torsional, Rotor, and Electronic Effects in 4-tert-Butylmethylenecyclohexane Epoxidations and...
DNA-Mediated Acid Catalysis: Calculations of the Rates of DNA-Catalyzed Hydrolyses of Diol Epoxides1 Gene Lamm, Linda Wong, and George R. Pack — pp 3325-3331 Kinetic and Mechanistic Analysis of Nonenzymatic, Template-Directed Oligoribonucleotide Ligation Rajat Rohatgi, David P. Bartel, and Jack W. Szostak — pp 3332-3339 Nonenzymatic, Template-Directed Ligation of...
Economy in Protein Design: Evolution of a Metal-Independent ββα Motif Based on the Zinc Finger Domains Mary D. Struthers, Richard P. Cheng, and Barbara Imperiali — pp 3073-3081 Mechanism of Stabilization of Helical Conformations of Polypeptides by Water Containing Trifluoroethanol Arthur Cammers-Goodwin, Thomas J. Allen, Sherri L. Oslick, Kim F. McClure, Janette H. Lee, and D....
Guanine Radical Cations Are Precursors of 7,8-Dihydro-8-oxo-2‘-deoxyguanosine But Are Not Precursors of Immediate Strand Breaks in DNA Paul M. Cullis, Mark E. Malone, and Louise A. Merson-Davies — pp 2775-2781 Molecular Modeling Studies on Oxidation of Hexopyranoses by Galactose Oxidase. An Active Site Topology Apparently Designed To Catalyze Radical Reactions, Either Concerted...
Azatides: Solution and Liquid Phase Syntheses of a New Peptidomimetic Hyunsoo Han and Kim D. Janda — pp 2539-2544 Synthesis and Physical Properties of Highly Sulfonated Polyaniline X.-L. Wei, Y. Z. Wang, S. M. Long, C. Bobeczko, and A. J. Epstein — pp 2545-2555 Novel Keto−Enol Systems: Cyclobutane Derivatives Patrick E. Lindner, Ricardo A. Correa, James Gino, and David M. Lemal...
Anthraquinone Photonucleases: Mechanisms for GG-Selective and Nonselective Cleavage of Double-Stranded DNA David T. Breslin and Gary B. Schuster — pp 2311-2319 DNA and RNA Modification Promoted by [Co(H2O)6]Cl2 and KHSO5: Guanine Selectivity, Temperature Dependence, and Mechanism James G. Muller, Ping Zheng, Steven E. Rokita, and Cynthia J. Burrows — pp 2320-2325 Role of the...
2-Keto-3-deoxy-6-phosphogluconate Aldolases as Catalysts for Stereocontrolled Carbon−Carbon Bond Formation Michael C. Shelton, Ian C. Cotterill, Sarah T. A. Novak, Rahib M. Poonawala, Sunil Sudarshan, and Eric J. Toone — pp 2117-2125 α−β Chimeric Oligonucleotides Form a New Stable “Snail-like” Structure M. B. Gottikh, O. A. Fedorova, M.-V. Baud-Demattei, S. Giorgi-Renault,...
On the Stereochemical Course of Human Protein-Farnesyl Transferase Mu, Charles A. Omer, and Richard A. Gibbs — pp 1817-1823 Voltage-Assisted Peptide Synthesis in Aqueous Solution by α-Chymotrypsin Immobilized in Polypyrrole Matrix Golam Faruque Khan, Eiry Kobatake, Hiroaki Shinohara, Yushihito Ikariyama, and Masuo Aizawa — pp 1824-1830 Group Additivity Analysis of the Heat...
Peptide-Mediated Release of Folate-Targeted Liposome Contents from Endosomal Compartments1 Karen Vogel, Susan Wang, Robert J. Lee, Jean Chmielewski, and Philip S. Low — pp 1581-1586 Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases Dongyu Liu, Sarah L. Daubendiek, Martin A. Zillman, Kevin Ryan, and Eric T. Kool — pp...
Electronically Excited States of 1,4:5,8-Bismethano-1,4,4a,5,8,8a-hexahydronaphthalene, a Nonconjugated Diene: Comparison of Theory and Experiment Daniel E. Love, Dana Nachtigallova, Kenneth D. Jordan, James M. Lawson, and Michael N. Paddon-Row — pp 1235-1240 Mechanisms of Inactivation of γ-Aminobutyric Acid Aminotransferase by 4-Amino-5-fluoro-5-hexenoic Acid Richard B....
Metal−Hydrogen Bond Dissociation Enthalpies in Series of Complexes of Eight Different Transition Metals Dongmei Wang and Robert J. Angelici — pp 935-942 Metal Coordination as a Method for Templating Peptide Conformation Zong-Qiang Tian and Paul A. Bartlett — pp 943-949 Probing the Specificity of the Serine Proteases Subtilisin Carlsberg and α-Chymotrypsin with Enantiomeric...
Surfactants Europa: A Directory of Surface Active Agents Available in Europe, 3rd Edition Edited by Gordon L. Hollis. Royal Society of Chemistry: Cambridge, U.K. 1995. xix + 459 pp. £80.00. ISBN: 0-85404-804-9. pp 3-4 Chemical Kinetics of Solids By H. Schmalzried (Universität Hannover, Germany). VCH: Weinheim, Germany. 1995. xii + 422 pp. $175.00. ISBN: 3-527-29094-X. H. F....
Elaboration of a General Strategy for Inhibition of myo-Inositol 1-Phosphate Synthase: Active Site Interactions of Analogues Possessing Oxidized Reaction Centers Marie E. Migaud and J. W. Frost — pp 495-501 Probing the Abilities of Synthetically Useful Serine Proteases To Discriminate between the Configurations of Remote Stereocenters Using Chiral Aldehyde Inhibitors Taekyu Lee...
Evidence for Concert in the Thermal Unimolecular Vinylcyclopropane to Cyclopentene Sigmatropic 1,3-Shift Joseph J. Gajewski, Leif P. Olson, and M. Robert Willcott — pp 299-306 Orthogonal Ligation of Unprotected Peptide Segments through Pseudoproline Formation for the Synthesis of HIV-1 Protease Analogs, Chuan-Fa Liu, Chang Rao, and James P. Tam — pp 307-312 Positive Halogens...